Liver function tests. It takes only a few minutes. The parathyroid gland may be functioning autonomously, independent of ambient calcium level. Alkaline phosphatase (ALP) is a glycoprotein and functions as an ectoenzyme attached to the outer surface of cells and matrix vesicles. Additional Information. Alkaline phosphatase (ALP)-induced in situ fluorescent immunosensor is less investigated and reported. Its concentrated in the liver, kidneys, gut, and bones. In patients with sickle cell disease, higher levels of alkaline phosphatase are associated with vaso-occlusive crises involving the bones [28]. which enables users to obtain detailed information and reports based on their genome. Bone alkaline phosphatase indicates bone-forming activity. Be sure to follow them. Pagets disease is a common disorder that affects bone strength and formation. The following are the km, vmax, and ki values found in the scientific literature for these inhibitors: L-Phenylalanine: km = 0.021 mM, vmax = 0.028 U/mg, ki = 0.088 mM. . Cinacalcet, a drug for chronic kidney disease, can reduce blood alkaline phosphatase levels by more than twenty percent in patients after 26 weeks of administration. Storage instructions. This indicates that under physiological conditions alkaline phosphatase activity toward pyridoxine 5'-phosphate is reduced approximately 50% by the normal phosphate concentration and that it will increase or decrease significantly in response to changes in phosphate concentration within the ranges observed clinically. Alkaline phosphatase Alkaline phosphatase (Alk Phos) is an enzyme found within the bone, liver, kidney and placenta and is a helpful differential. Once they have enough blood to test, theyll remove the needle and hold a cotton ball or gauze on the site to stop the bleeding. integrin antagonists (e.g., beta-2 integrin antagonists), adenosine A2a agonists, mediator release inhibitors such as sodium chromoglycate, 5-lipoxygenase inhibitors (zyflo), DP1 . Efavirenz, an anti-HIV drug, is associated with increased alkaline phosphatase levels in HIV patients. 1996 Dec;103(12):491-3. ALP levels also vary with age and gender, with levels higher in children and pregnant women [1]. Each tablet contains the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose acetate succinate, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulfate. Alkaline phosphatase activity was determined by treating 10 g of soil with 2.5 mL of toluene and 10 mL of p-nitrophenol phosphatase solution. Production by myeloma cells of Dickkopf-1 (DKK-1) protein, a soluble inhibitor of signaling via the Wnt pathway, an important growth factor pathway for osteoblasts, has been implicated in the suppression of osteoblast . 8600 Rockville Pike He has a history of peer-reviewed publications, intellectual property discoveries (patents, etc. Stop smoking, as it can increase ALP levels [34]. A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. In excess or deficiency, this enzyme can lead to a broad range of diseases [3]. You will be asked to fast for 10 to 12 hours before the test to ensure an accurate reading. Your age teens and children may have higher levels because their bones are growing. Bethesda, MD 20894, Web Policies ALP levels then rise again in old age. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. What to Expect During Liver Function Tests, High Ammonia Levels: Symptoms, Causes, Treatment, High Bilirubin Levels in Babies and Adults, Transaminitis (Liver Enzyme) Result: Meaning and Causes. Scientists have not yet identified the full range of biochemical reactions that ALP instigates, but the enzyme is known to contribute to the following processes: ALP is found in all tissues of the body but, not surprisingly, is found in its highest concentration in the liver, bones, kidneys, and intestines as well as the bile ducts (that drain bile from the liver) and gallbladder (that stores bile). An ALP test is often included in a comprehensive metabolic panel (CMP) and liver panel. ALP levels are typically elevated during childhood and puberty due to bone growth and development. Store at -20C. 2021 Nov 5;12:734539. doi: 10.3389/fphar.2021.734539. Alkaline phosphatase staining kit. If you have a liver or bone condition or another type of condition, your provider may order an ALP test, often as part of a panel, to monitor your condition to see if its improving, worsening or staying the same with or without treatment. He received his undergraduate education at the University of California at Irvine, a Medical Doctorate from the University of Southern California, and was a Resident Physician at Stanford University. Your doctor will interpret your results in conjunction with your medical history and other test results. Increased alkaline phosphatase levels are also correlated with hyperthyroidism [12]. Ideally, the purified wild-type enzyme from Lab 3 would be used in this experiment, but . People with blocked bile flow and various types of cancers are more likely to have high alkaline phosphatase levels. Your liver has the capacity to regenerate. Remember that some lab-to-lab variability occurs due to differences in equipment, techniques, and chemicals used. ALP values that fall outside these reference ranges are considered abnormal. Alkaline phosphatase is an enzyme that helps you digest food and maintain strong bones. 1967 Sep;104(3):1011-8. doi: 10.1042/bj1041011. Moreover, NSFtreated DCs release a second 20kDa NSF (NSF int ). Alkaline phosphatase (ALP) is an enzyme found in the blood that helps break down proteins. About 95% of the total ALP activity is derived from bone and liver sources, which occur in a ratio of If youve been diagnosed with a liver condition or a bone disorder and are experiencing new or concerning symptoms, contact your provider. Coming to a Cleveland Clinic location?Cole Eye entrance closingVisitation, mask requirements and COVID-19 information. While you can undergo a blood test that just measures your ALP, its most often included in a panel with other measurements, such as liver enzymes, to get a more complete picture of your livers health. Talk to your doctor about how to improve your liver health and read our 6-step protocol for liver regeneration. Fortuna R, Anderson HC, Carty R, Sajdera SW. Biochim Biophys Acta. Unable to load your collection due to an error, Unable to load your delegates due to an error. 2022 Oct 18;14(10):2222. doi: 10.3390/pharmaceutics14102222. L-Homoarginine (10 mmol/1), an inhibitor of the liver and bone isoenzymes, inhibited the seminal enzyme (53%), whereas L-phenylalanine (12 mmol/1), a strong inhibitor of placental alkaline phosphate, However, its important to remember that a normal test doesnt mean a particular medical condition is absent. Biochemical, clinical and genetic characteristics in adults with persistent hypophosphatasaemia; Data from an endocrinological outpatient clinic in Denmark. 102000002260 Alkaline Phosphatase Human genes 0.000 description 1; Alkaline phosphatase (ALP) is an enzyme thats found throughout your body. Other factors can affect your levels, including: Before determining if you need to undergo further tests, your healthcare provider will take into consideration many aspects of your health and situation, including: If youre experiencing symptoms of liver damage, such as jaundice, or bone disorders, such as bone or joint pain, call your healthcare provider. alkaline phosphatase (alkp) is an enzyme that catalyzes the hydrolysis of organic pyrophosphate, 12 an inhibitor of vascular calcification. Oxyanions such as vanadate [7-9], molybdate, and tungstate [17, 20] are, in general, known to be competitive inhibitors of phosphatase enzymes. Function & Normal Range. Some good options include milk thistle, NAC, taurine, B vitamins, and vitamin C. Additionally, get enough sun, exercise, omega-3 fatty acids, and coffee. What is Alkaline Phosphatase? Your email address will not be published. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at support@selfhacked.com. Eur J Intern Med. Efficient Synthesis for a Wide Variety of Patellamide Derivatives and Phosphatase Activity of Copper-Patellamide Complexes. We do not aim to diagnose, treat, cure or prevent any illness or disease. However, researchers believe its important for multiple different processes. Hydroxy-Safflower Yellow A Alleviates Osteoporosis in Ovariectomized Rat Model by Inhibiting Carbonic Anhydrase 2 Activity. Function & Normal Range, Low Alkaline Phosphatase Symptoms, Causes & Meaning, Dark-colored urine and/or light-colored stool. High alkaline phosphatase doesnt cause any symptoms directly. Sodium phosphate buffer (0.5 ml, 0.1 M, pH 7.4) was added to the direct mutagen-containing tubes, and 0.5 ml of 10% S9 mix was added to the indirect mutagen-containing tubes. The symptoms we discuss here are commonly associated with high alkaline phosphatase levels, but are not enough for a diagnosis. Higher ALP levels can occur in people with blood group B or blood group O [2]. NSF is a 45kDa protein released from the macrophagelike suppressor cells and binds selectively to dendritic cells (DCs). A general ALP test is usually included in a blood test known as a comprehensive metabolic panel (CMP) and a liver panel (HFP or LFT). 2018;7:2. doi:10.4172/2167-0889.1000228. Both enzyme units and microkatals are measurements of an enzyme's catalytic activity. While an isoenzyme test can provide more detailed information, its more technically challenging and expensive, and some laboratories may not offer it. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. An alkaline phosphatase (ALP) test measures the amount of ALP in your blood. Alkaline phosphase (ALP). Enlarged or abnormally shaped bones. The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. The results of other tests usually taken alongside ALP. Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. Verywell Health's content is for informational and educational purposes only. Ashraf J, Mughal EU, Alsantali RI, Sadiq A, Jassas RS, Naeem N, Ashraf Z, Nazir Y, Zafar MN, Mumtaz A, Mirzaei M, Saberi S, Ahmed SA. Alkaline phosphatase is found in a multitude of different organisms performing the same function in all but with differing structural forms that change with regard to the environment. Be sure to let your doctor know if you are pregnant, because that will increase the level of ALP in your blood. When the test is done, the lab tech will take the tourniquet off, and youll get a bandage on the spot where the needle went in. Usually, it's a combination of important enzymes such as the intestinal alkaline phosphate, placenta alkaline phosphates, and non-specific alkaline phosphate. Would you like email updates of new search results? This indicates that under physiological conditions alkaline phosphatase activity toward pyridoxine 5-phosphate is reduced approximately 50% by the normal phosphate concentration and that it will increase or decrease significantly in response to changes in phosphate concentration within the ranges observed clinically. Lineweaver-Burk Plot for the Reaction of Alkaline Phosphatase and p-nitrophenol phosphate with L-Phenylalanine Inhibitor at Different Concentrations. Alkaline phosphatases (orthophosphoric monoester phosphohydrolase, EC 3.1.3.1) from brain, kidney, liver, bone, lung and spleen, which are not very sensitive to l -phenylalanine, are strongly inhibited by imidazole, whereas the placental and intestinal enzymes, which are very sensitive to l -phenylalanine, are only slightly affected. Mammalian alkaline phosphatase isoenzymes are inhibited by homoarginine and levamisole analogs. The .gov means its official. The samples are sent to a lab where a medical laboratory scientist prepares the samples and performs the test on machines known as analyzers. (IC 50 = 0.045 0.004 M), which is 116-fold more active than monopotassium phosphate (IC 50 = 5.242 . 2022 Apr 22;28(23):e202200249. . 2. Some medicines interfere with the results, so make sure your doctor knows about all drugs you take, including over-the-counter medicines, vitamins, and supplements. An enzyme known as alkaline phosphatase can be stopped from functioning when it is exposed to urea, L-phenylalanine, or phosphate. His previous clients include Allergan, Caladrius Biosciences, and Omega Protein. Accessibility Dont be afraid to ask your provider questions. The predominant. Whereas an ALP test just measures the level of ALP in your blood, an ALP isoenzyme test can differentiate between types of alkaline phosphatase based on where they originated in your body. Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. Natural and artificial manipulation of tissue nonspecific alkaline phosphatase activity indicates that pyrophosphate, phosphoethanolamine, and pyridoxal 5'-phosphate are among the natural substrates for this enzyme. There are two main types of alkaline phosphatase (ALP) blood tests: a general ALP (the more common test) and an ALP isoenzyme test. [1]: Go to SelfDecode to learn how your genes can influence your alkaline phosphatase levels. You may have slight tenderness or a bruise at the site of the blood draw, but this usually resolves quickly. Clin Liver Dis. Alkaline phosphatase (ALP) is an enzyme found in the blood that helps break down proteins. You have alkaline phosphatase throughout your body, including your liver, digestive system, kidneys, and bones. It improves digestion, makes your bones strong, and keeps your mind sharp. J Liver. Inhibition of alkaline phosphatase from human placenta and intestine by inorganic phosphate. An ALP test measures how much of this enzyme is circulating in the blood stream. Symptoms of high alkaline phosphatase depend on your underlying health condition such as liver disease or bone disorders. Celiac disease is an autoimmune condition where the immune system attacks the gut lining upon gluten consumption. The developed platform was based on a fluorogenic self-assembly reaction between pyridineboronic acid (PyB(OH) 2) and alizarin red S (ARS).We first used density functional theory (DFT) to . Never implement them in place of what your doctor recommends or prescribes. Information is shared for educational purposes only. Blood tests are a very common and essential part of medical testing and screening. The ALP test, which measures the amount of alkaline phosphatase in a sample of blood, is routinely ordered to help diagnose suspected diseases and is usually performed with other blood tests to help narrow down the possible causes. If you have any questions about youre alkaline phosphatase results, dont be afraid to ask your provider questions. ALP is often considered a liver enzyme because its primarily found in your liver. sharing sensitive information, make sure youre on a federal Slightly abnormal ALP levels. Alkaline phosphatase is an enzyme that helps fight off bad bacteria in the gut. Screening means checking for potential health issues before you experience symptoms. Youll sit in a chair, and a healthcare provider will check your arms for an easily accessible vein. It also increases bone mineralization, which is likely due to the increased enzyme function [14]. ALP plays a role in numerous processes in the human body, and any abnormalities in blood concentrationseither high or lowmay be indicative of diseases ranging from gallstones and thyroid disease to hepatitis and cancer. ALP tests play an important role in the diagnosis of liver disease. EJIFCC. Vitamin D deficiency is usually accompanied by elevated levels of total alkaline phosphatase in the blood. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. Alkaline phosphatase (ALP) levels that are considered normal differ by age and status of pregnancy. Rare genetic conditions, including hypophosphatasia and. a phosphate monoester + H 2 O = an alcohol + phosphate. University of Rochester Medical Center Health Encyclopedia: Alkaline Phosphatase., The Science Museum (U.K.): Your Body -- What Do Your Cells Do?, National Institutes of Health, Genetics Home Reference: ALPL gene., American Association for Clinical Chemistry: Lab Tests Online -- ALP., Kids Health by Nemours Foundation: Blood Test -- Hepatic (Liver) Function Panel.. Your healthcare provider will compare your lab test results with reference values to see if your chloride results fall outside the range of expected values. It may indicate the following conditions: If your ALP test result is high or low, it doesn't necessarily mean that you have a medical condition that needs treatment. Once theyve located a vein, theyll clean and disinfect the area. Physiological role of alkaline phosphatase explored in hypophosphatasia. Symptoms of High Prolactin Hormone Levels, ALT and AST Enzymes: Meaning of Low, Normal, High Levels, MCHC Blood Test Results: Meaning of Low and High Levels. Inhibitors for Acid phosphatase The inhibition of acid phosphatase by inorganic phosphate. The https:// ensures that you are connecting to the If your liver isnt working right, the amount of ALP in your blood may be high. Solution for Is Sodium Phosphate A Competitive Or Noncompetitive Inhibitor Of Alkaline Phosphatase? Thank you, {{form.email}}, for signing up. Last reviewed by a Cleveland Clinic medical professional on 11/04/2021. We examined the kinetics of tissue nonspecific alkaline phosphatase from bovine kidney and sera from 49 patients with a wide range of endogenous phosphate concentrations using pyridoxine 5'-phosphate as a substrate at pH 7.4. Publication types High levels of ALP in your blood may indicate liver disease or certain bone disorders. We believe that the most accurate information is found directly in the scientific source. Get more sun, exercise, and consider upping your coffee intake to lower your alkaline phosphatase. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. What Is an Alkaline Phosphatase (ALP) Blood Test? Other conditions that can cause problems with your liver include: The test can also spot problems with your bones, including: The lab will need a small amount of blood to perform the test. An enzyme is a type of protein in a cell that acts as a catalyst and allows certain bodily processes to happen. Unlike the native surface of the implant material (Ti6Al4V), oxidation with H2O2 leads to increased binding of the effective antimicrobial agent poly(hexamethylene . Read on to understand the symptoms and causes of high alkaline phosphatase and how to reduce it naturally. Indian J Clin Biochem. There are thousands of enzymes throughout your body that have important functions. A result that is slightly low/high may not be of medical significance, as this test often varies from day to day and from person to person. Joe Cohen won the genetic lottery of bad genes. Careers. Alzheimers patients have higher tissue-nonspecific alkaline phosphatase levels compared to healthy patients. Phone: 760-431-4600 / Fax: 760-431-4604. Women with breast cancer had elevated levels of alkaline phosphatase compared to normal healthy women. 15) Liver Problems Associated with Celiac Disease. You may feel a little sting when the needle goes in or out. A description of alkaline phosphatase, a test for liver function (part of the Just Diagnosed lesson for patients), from the VA National Viral Hepatitis and Liver Disease Program. As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine. 1977 Feb;25(2):352-4. doi: 10.1248/cpb.25.352. High alkaline phosphatase (ALP) levels may indicate that theres damage to your liver or that you have a type of bone disorder. L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase. Authors M Sugiura, K . If you only have a mild elevation in your ALP levels, your healthcare provider will likely not have you undergo extensive evaluation. Alkaline phosphatase is a glycoprotein with a molecular weight of 140,000. High alkaline phosphatase (above 130 U/L) may point to liver, gallbladder, or bone disorders. An error in the collection, transport or processing of the test. is a clickable link to peer-reviewed scientific studies. (Children and teens naturally have higher levels than adults because their bones are still developing). In balance, it protects your gut against harmful bacteria and aids digestion. We do not endorse non-Cleveland Clinic products or services. Higher-than-normal ALP levels for your age and sex may not necessarily mean you have a problem. Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA . By contrast, certain diseases or conditions can impair ALP synthesis and lead to a drop in the blood concentration. The symptoms will depend on your underlying health issuesuch as liver or bone disorders. Alkaline phosphatase is an enzyme found in all tissues in the human body. Cleveland Clinics Robert J. Tomsich Pathology & Laboratory Medicine Institute touches virtually every patient at Cleveland Clinic and thousands of patients across the world. The placenta alkaline phosphatase level is a useful biomarker to help diagnose and treat leukemia [21]. Alkaline phosphatase is high if the blood levels surpass 130 U/L. PHPS1 (PTP Inhibitor V), a potent and cell-permeable inhibitor, is specific for Shp2 with Ki value of 0.73 M. Cleveland Clinic is a non-profit academic medical center. Estrogen is also able to regulate the growth and expression of this enzyme in human bone marrow cell culture [16]. If bilirubin, ALT, and AST values are normal, it would indicate that the liver is not involved and allow the healthcare provider to look elsewhere for a cause. Although inorganic phosphate has been recognized as a competitive inhibitor of this enzyme for many years, the influence of phosphate on alkaline phosphatase activity in serum under physiological conditions has not been previously reported. Although ALP exists throughout your body, the two main sources of ALP in your blood are your liver and bones. If your alkaline phosphatase (ALP) test is part of a comprehensive metabolic panel (CMP), youll likely need to fast for 10 to 12 hours before your CMP blood test. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Work with your doctor to find out what causes your high alkaline phosphatase levels. PHPS1. In: StatPearls. The ALP test involves a simple blood draw performed by a nurse, healthcare provider, or phlebotomist. Always talk to your doctor about any lifestyle and dietary interventions that you plan to implement. Do not freeze. Each subunit (69,000 molecular weight) contains a tightly bound zinc atom that contributes to the structural integrity of the polypeptide and a less tightly bound zinc atom that is required for catalysis. Abnormally high levels of bone alkaline phosphatase can be an indicator of bone turnover, so while the enzyme does not cause the disease, it can be a helpful indicator [23]. Hanley S, Brown J, Timmins P, Davies C, Dennis A. Pharmaceutics. It is a dimer of two very similar or identical subunits. Theres also a slight chance of infection. In untrained male subjects, one single bout of resistance exercise can cause bone ALP activity to significantly decrease two and three days after the exercise [37]. An official website of the United States government. 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 5; . High levels of ALP may indicate liver disease or certain bone disorders, but an ALP test alone cannot diagnose a condition. MeSH 2012;16(2):199-229. doi:10.1016/j.cld.2012.03.012. The kinetics of inhibition of calf-intestinal alkaline phosphatase by inorganic phosphate, fluorophosphate, inorganic pyrophosphate, beta-glycerophosphate and adenosine 5'-triphosphate in the range pH8-10 were investigated. Storage. Its also important to note that normal alkaline phosphatase levels vary with age and sex. Sign in or Register. Alkaline phosphatase Inhibitors related products. Clipboard, Search History, and several other advanced features are temporarily unavailable. If they do, what type of inhibitor (competitive or uncompetitive) are they? It can confirm whether a bone condition is causing the ALP elevation as opposed to the liver.. 2022 Dotdash Media, Inc. All rights reserved. Align your health hacks with your genes for optimal health & cognitive function. After preincubation at 37 C in a shaking water bath for 30 min, 2 ml of top agar containing 10% histidine/biotin solution was added and then spread on a minimal . ALP values are higher in children because their bones are actively growing, while the ALP values increase during pregnancy in tandem with the development of the placenta and the approach of childbirth. High liver alkaline phosphatase levels are associated with bile duct obstruction and liver cancer. This site needs JavaScript to work properly. Having an abnormally low level of alkaline phosphatase (ALP) is less common than having an elevated level. WORLDWIDE DISTRIBUTION. Cissus quadrangularis, a type of plant from the grape family, significantly increases alkaline phosphatase activity in cell culture. 45Kda protein released from the macrophagelike suppressor cells and matrix vesicles is sodium phosphate a Competitive or Noncompetitive of... Issues before you experience symptoms ):2222. doi: 10.1248/cpb.25.352:2222. doi: 10.1042/bj1041011 metabolic (... ):1011-8. doi: 10.1042/bj1041011 for liver regeneration contrast, certain diseases or can! 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In the blood concentration about how to improve your liver and bones liver disease or certain bone.... Enzyme that helps you digest food and maintain strong bones Data from an outpatient. Certain bodily processes to happen its also important to note that normal phosphatase! Usually taken alongside ALP Oct 18 ; 14 ( 10 ):2222. doi: 10.1042/bj1041011 panel ( CMP ) liver! More technically challenging and expensive, and several other advanced features are temporarily unavailable alkaline phosphatase inhibitor sodium phosphate ; from... Meaning, Dark-colored urine and/or light-colored stool, etc variability occurs due to bone growth and of! With hyperthyroidism [ 12 ] commonly associated with high alkaline phosphatase ( ALP ) is an inhibitor of alkaline..., or phosphate in HIV patients [ 2 ] needle is inserted, small... Yellow a Alleviates Osteoporosis in Ovariectomized Rat Model by Inhibiting Carbonic Anhydrase 2 activity [ 1:! Of plant from the macrophagelike suppressor cells and matrix vesicles endorse non-Cleveland Clinic products or services of blood will collected. Enzyme in human bone marrow cell culture [ 16 ] alkaline phosphatase inhibitor sodium phosphate condition where the immune system attacks gut! Genes can influence your alkaline phosphatase throughout your body that have important functions sensitive information, more! Disinfect the area occurs due to differences in equipment, techniques, and bones levels compared to healthy. How your genes can influence your alkaline phosphatase human genes 0.000 description ;... Dcs release a second 20kDa NSF ( NSF int ) entrance closingVisitation, requirements... Site of the test to ensure an accurate reading, researchers believe its important for multiple different processes:... To normal healthy women intake to lower your alkaline phosphatase levels vary with age and gender, levels. Blocked bile flow and various types of cancers are more likely to have high alkaline human! Optimal health & cognitive function gender, with levels higher in children and teens have! As alkaline phosphatase levels hours before the test when the needle is inserted, a small amount of ALP indicate... Inhibition of Acid phosphatase by inorganic phosphate elevated during childhood and puberty due bone.: Go to SelfDecode to learn how your genes can influence your alkaline phosphatase human genes 0.000 5. During childhood and puberty due to bone growth and development any illness or disease only sources...